We claim: 1. A method, for monitoring and screening for active ligands of nucleic acid targets, the method comprising; providing the nucleic acid target having been modified by the inclusion of 2-aminopurine; introducing a ligand so as to cause interactions between the ligand and the nucleic acid target; and measuring the interactions, wherein said measuring comprises the detection of any modulation in the fluorescence properties of the 2-aminopurine resulting from changes in the conformation of the nucleic acid target bound by the ligand; wherein the target is a modified rev response element (RRE) having a stem-loop IIB, the stem-loop IIB comprising SEQ ID NO: 1. 2. The method of claim 1, wherein the modified rev response element (RRE) includes a 2-aminopurine at a position 72 of the stem-loop IIB. 3. The method of claim 2, wherein the rev response element (RRE) further includes a 2-aminopurine at position 68 of the stem-loop IIB. 4. The method of claim 1, wherein the rev response element (RRE) includes a 2-aminopurine at position 68 of the stem-loop IIB. 5. The method of claim 1, further comprising determining the fluorescence of the modified rev response element (RRE) prior to said introducing the ligand, and comparing the result of said determining to the result of said measuring to ascertain any difference in fluorescence. 6. The method of claim 1, wherein the ligand is an inhibitor of the binding of rev to the rev response element (RRE), and said measuring comprises determining a level of inhibition. 7. The method of claim 3, further comprising introducing rev to the RRE and ligand, wherein said measuring comprises determining a level of RRE-rev inhibition caused by the ligand. 8. The method of claim 7, further comprising: providing a modified RRE having a 2-aminopurine at positions 68 and 72 of stem-loop IIB; introducing the ligand to the modified RRE; and measuring interactions between the modified RRE and the ligand to determine a level of binding. 9. The method of claim 8, further comprising: optimizing the ligand following said measuring steps; providing the RRE including a 2-aminopurine at position 72 of a stem-loop IIB; introducing said optimized ligand to the RRE including a 2-aminopurine at position 72 of stem-loop IIB and rev; and measuring the level of inhibition caused by the optimized ligand. 10. The method of claim 9, further comprising: providing the modified RRE having a 2-aminopurine at positions 68 and 72 of stem-loop IIB; introducing the optimized ligand to a second unlabeled REE with altered sequence; and measuring interactions between the second REE and the ligand to determine a level of binding specificity between the modified REE and the optimized ligand. 11. A method for monitoring and screening for active ligands to a nucleic acid sequence comprising: providing a nucleic acid sequence, modified by the inclusion of 2-aminopurine; introducing a ligand; and measuring interactions between the nucleic acid sequence and the ligand as detected using 2-aminopurine fluorescence resulting from changes in the conformation of the nucleic acid target when bound by the ligand, wherein said sequence is a dimerization initiation site stem-loop. 12. The method of claim 11, wherein the dimerization initiation site stem-loop includes 2-aminopurine in at least one of the positions selected from the group consisting of a position 4 and position 12 of the sequence. 13. A method for monitoring and screening for active ligands to a nucleic acid sequence comprising: providing a nucleic acid sequence, modified by the inclusion of 2-aminopurine introducing a ligand; and measuring interactions between the nucleic acid sequence and the ligand as detected using 2-aminopurine fluorescence which may result from changes in the conformation of the nucleic acid target when bound by the ligand, wherein the sequence is a consensus binding sequence for a topoisomerase. 14. The method of claim 13, wherein the binding sequence includes SEQ ID NO: 10. 15. The method of claim 14, further comprising determining inhibition of interaction between DNA and the topoisomerase. 16. An assay kit for identifying a compound that inhibits the binding of HIV rev to HIV RRE comprising: a ligand; to the RRE rev protein; a modified RRE, having a stem-loop IIB comprising SEQ ID NO: 1, including 2-aminopurine; and means for determining any competitive inhibition of binding of rev to the modified REE by the compound. 17. The assay kit of claim 16, wherein the RRE includes 2-aminopurine at positions selected from only position 68, only position 72 and both position 68 and 72 of the stem-loop IIB. 18. The assay kit of claim 17, wherein said modified RRE includes 2-aminopurine at a position 72 of the stem-loop IIB. 19. The assay kit of claim 17, wherein said modified RRE includes 2-aminopurine at a position 68 and a position 72 of the stem-loop IIB. 20. The assay kit of claim 17, further comprising: means for contacting the ligand with a modified REE, including 2-aminopurine at positions 68 and 72 of a stem-loop IIB; and a second means for determining a degree of binding between the ligand and the modified RRE, having 2-aminopurine at a position 68 and a position 72 of the stem-loop IIB. 21. The assay kit of claim 20, further comprising: an optimized ligand; modified RRE, having 2-aminopurine at position 72 of the stem-loop IIB; modified RRE, having 2-aminopurine at a position 68 and a position 72 of the stem-loop IIB means for determining change in binding of rev to modified RRE, having 2-aminopurine at position 72 of the stem-loop IIB, caused by said optimized ligand and means for determining the degree of binding between said optimized ligand and the modified RRE, having 2-aminopurine at positions 68 and 72 of the stem-loop IIB. 22. An assay kit for identifying a compound that inhibits the binding HIV rev to HIV RRE, comprising: a first modified RRE, including 2-aminopurine at a position 72 of a stem-loop IIB, the stem-loop IIB comprising SEQ ID NO: 1; and a second modified RRE, including 2-aminopurine at a position 68 and a position 72 of the stem-loop IIB, the stem-loop IIB comprising SEQ ID NO: 1.